GLAUCOMA : OCULAR ALZHEIMER ’ S DISEASE ? Stuart
نویسنده
چکیده
1. Abstract 2. Introduction 2.1. Apoptosis 2.2. Caspases 2.2. Apoptosis and glaucoma 2.3. Caspase substrates in Alzheimer's disease 3. Methods 3.1. Chronic ocular hypertensive rat glaucoma model 3.2. Intraocular pressure (IOP) measurement and analysis 3.3. Optic nerve axon counts 3.4. Immunohistochemistry 3.5. Immunogold electron microscopy 3.6. ELISA 4. Rat model of chronic ocular hypertension 4.1. Retinal gene expression 4.2. Caspase activation 4.3. Abnormal processing of amyloid precursor protein 5. Delayed apoptosis in rat glaucoma 5.1. Caspase inhibition in rat glaucoma using AAV-mediated gene therapy 6. Conclusions and Perspectives 6.1. Similarities between glaucoma and Alzheimer's disease (AD) 6.2. Vascular pathology in glaucoma and Alzheimer's disease 7. Acknowledgements 8. References
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